Duragesic Mat e Imipramine Capsules
Determinazione dell'interazione di Duragesic Mat e Imipramine Capsules e della possibilità della loro somministrazione congiunta.
Nella database di manuali utilizzati per creare il servizio, è stata trovata un'interazione statisticamente registrata dai risultati della ricerca, che può portare alle conseguenze negative per la salute del paziente o rafforzare un effetto positivo reciproco. È necessaria la consultazione del medico per risolvere il problema della co-somministrazione di medicinali.
Consumatore:Uso di fentanil insieme con imipramine può aumentare il rischio di una condizione rara, ma grave chiamata sindrome serotoninergica, che possono includere sintomi quali confusione, allucinazioni, convulsioni, forti sbalzi della pressione arteriosa, aumento della frequenza cardiaca, febbre, sudorazione, brividi o tremori, visione offuscata, spasmi muscolari o rigidità, tremori, incoordinazione, crampi allo stomaco, nausea, vomito e diarrea. Casi più gravi può provocare coma e anche la morte. Si dovrebbe cercare immediatamente assistenza medica se si verificano questi sintomi durante l'assunzione di farmaci. Parlate con il vostro medico se avete domande o dubbi. Il medico può già essere consapevoli dei rischi, ma ha deciso che questo è il miglior corso di trattamento per voi, e ha preso le opportune precauzioni e sta monitorando con attenzione e per eventuali complicazioni. È importante informare il vostro medico su tutti gli altri farmaci in uso, tra cui le vitamine e le erbe. Non smettere di usare i farmaci senza prima parlare con il medico.
Professionista:MONITORARE ATTENTAMENTE: l'uso Concomitante di agenti serotoninergici attività come inibitori della ricaptazione della serotonina, inibitori delle monoamino ossidasi, inibitori, antidepressivi triciclici, 5-HT1 agonisti del recettore, alcaloidi della segale cornuta, cyclobenzaprine, litio, erba di San Giovanni, fenilpiperidina oppiacei, destrometorfano, e triptofano può potenziare il rischio di sindrome da serotonina, che è una rara, ma grave e potenzialmente fatale condizione pensato per derivare da iperstimolazione del tronco encefalico 5-HT1A e 2A recettori. I sintomi della sindrome serotoninergica possono includere cambiamenti dello stato mentale, come irritabilità, alterazione della coscienza, confusione, allucinazione, e coma; disfunzione autonomica come tachicardia, ipertermia, sudorazione, brividi, pressione sanguigna labilità, e midriasi; anomalie neuromuscolari come iperreflessia, mioclono, tremore, rigidità, e atassia; e sintomi gastrointestinali come crampi addominali, nausea, vomito e diarrea.
GESTIONE: In generale, l'uso concomitante di più serotoninergici agenti dovrebbero essere evitati, se possibile, o altrimenti si avvicinò con cautela, se il potenziale beneficio è ritenuto superino il rischio. I pazienti devono essere attentamente monitorati per i sintomi della sindrome serotoninergica durante il trattamento. Particolare si consiglia cautela quando si aumenta il dosaggio di questi agenti. Il potenziale di rischio per la sindrome da serotonina dovrebbe essere presa in considerazione anche quando la somministrazione di agenti serotoninergici in sequenza, come alcuni agenti possono dimostrare di possedere una prolungata emivita di eliminazione. Per esempio, alcuni esperti consigliano un della durata di 5 settimane periodo di washout dopo l'uso di fluoxetina e 3 settimane dopo l'uso di vortioxetine prima di somministrare un altro serotoninergici agente. Individuale di etichettatura dei prodotti per il lavaggio periodi dovrebbe essere consultato per le attuali raccomandazioni. Se la sindrome da serotonina si sviluppa o si sospetta durante il corso della terapia, tutti i serotoninergici agenti deve essere interrotto immediatamente e di sostegno, di cura reso necessario. Meno gravi, i pazienti possono anche trarre beneficio dalla somministrazione di un antagonista della serotonina (ad esempio, ciproeptadina, clorpromazina). I casi gravi devono essere gestiti in consultazione con un tossicologo e può richiedere la sedazione, paralisi neuromuscolare, l'intubazione e la ventilazione meccanica in aggiunta alle altre misure.
- Paruchuri P, Godkar D, Anandacoomarswamy D, Sheth K, Niranjan S "Rare case of serotonin syndrome with therapeutic doses of paroxetine." Am J Ther 13 (2006): 550-552
- Dougherty JA, Young H, Shafi T "Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine." Ann Pharmacother 36 (2002): 1647-1648
- "Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America, Lincolnshire, IL.
- Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8
- George TP, Godleski LS "Possible serotonin syndrome with trazodone addition to fluoxetine." Biol Psychiatry 39 (1996): 384-5
- Ruiz F "Fluoxetine and the serotonin syndrome." Ann Emerg Med 24 (1994): 983-5
- Thomas CR, Rosenberg M, Blythe V, Meyer WJ 3rd "Serotonin syndrome and linezolid." J Am Acad Child Adolesc Psychiatry 43 (2004): 790
- Rang ST, Field J, Irving C "Serotonin toxicity caused by an interaction between fentanyl and paroxetine." Can J Anaesth 55 (2008): 521-5
- Bergeron L, Boule M, Perreault S "Serotonin toxicity associated with concomitant use of linezolid." Ann Pharmacother 39 (2005): 956-61
- "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.
- "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC, New Haven, CT.
- "Product Information. Maxalt (rizatriptan)." Merck & Co, Inc, West Point, PA.
- Morales N, Vermette H "Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine." Psychosomatics 46 (2005): 274-5
- Skop BP, Finkelstein JA, Mareth TR, Magoon MR, Brown TM "The serotonin syndrome associated wtih paroxetine, an over-the-counter cold remedy, and vascular disease." Am J Emerg Med 12 (1994): 642-4
- "Product Information. Zomig (zolmitriptan)." Zeneca Pharmaceuticals, Wilmington, DE.
- Hammerness P, Parada H, Abrams A "Linezolid: MAOI Activity and Potential Drug Interactions." Psychosomatics 43 (2002): 248-9
- "Product Information. Flexeril (cyclobenzaprine)." Merck & Co, Inc, West Point, PA.
- Gordon JB "SSRI's and St. John's Wort: possible toxicity?" Am Fam Physician 57 (1998): 950,953
- Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13
- Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics." J Clin Psychopharmacol 10 (1990): 48-50
- Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8
- Morales-Molina JA, Mateu-de Antonio J, Marin-Casino M, Grau S "Linezolid-associated serotonin syndrome: what we can learn from cases reported so far." J Antimicrob Chemother 56 (2005): 1176-8
- Duggal HS, Fetchko J "Serotonin syndrome and atypical antipsychotics." Am J Psychiatry 159 (2002): 672-3
- Perry NK "Venlafaxine-induced serotonin syndrome with relapse following amitriptyline." Postgrad Med J 76 (2000): 254-6
- Rosebraugh CJ, floxkhart DA, Yasuda SU, Woosley RL "Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient." J Clin Pharmacol 41 (2001): 224-7
- Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6
- "Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals, Raritan, NJ.
- Roy S, Fortier LP "Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine." Can J Anaesth 50 (2003): 32-5
- Nijhawan PK, Katz G, Winter S "Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission." Crit Care Med 24 (1996): 1086-9
- "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals, St. Louis, MO.
- DeBellis RJ, Schaefer OP, Liquori M, Volturo GA "Linezolid-associated serotonin syndrome after concomitant treatment with citalopram and mirtazepine in a critically ill bone marrow transplant recipient." J Intensive Care Med 20 (2005): 351-3
- Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2
- Mackay FJ, Dunn NR, Mann RD "Antidepressants and the serotonin syndrome in general practice." Br J Gen Pract 49 (1999): 871-4
- "Product Information. Meridia (sibutramine)." Knoll Pharmaceutical Company, Whippany, NJ.
- Strouse TB, Kerrihard TN, Forscher CA, Zakowski P "Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine." J Clin Psychopharmacol 26 (2006): 681-683
- Boyer EW, Shannon M "The serotonin syndrome." N Engl J Med 352 (2005): 1112-20
- "Product Information. D.H.E. 45 (dihydroergotamine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Zyvox (linezolid)" Pharmacia and Upjohn, Kalamazoo, MI.
- Jones SL, Athan E, O'Brien D "Serotonin syndrome due to co-administration of linezolid and venlafaxine." J Antimicrob Chemother 54 (2004): 289-90
- "Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.
- Bhatara VS, Magnus RD, Paul KL, Preskorn SH "Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms." Ann Pharmacother 32 (1998): 432-6
- Steinberg M, Morin AK "Mild serotonin syndrome associated with concurrent linezolid and fluoxetine." Am J Health Syst Pharm 64 (2007): 59-62
- "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
- Lavery S, Ravi H, McDaniel WW, Pushkin YR "Linezolid and serotonin syndrome." Psychosomatics 42 (2001): 432-4
- Weiner AL "Meperidine as a potential cause of serotonin syndrome in the emergency department." Acad Emerg Med 6 (1999): 156-8
- Hachem RY, Hicks K, Huen A, Raad I "Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients." Clin Infect Dis 37 (2003): E8-E11
- "Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
- "Product Information. Savella (milnacipran)." Forest Pharmaceuticals, St. Louis, MO.
- Keegan MT, Brown DR, Rabinstein AA "Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs." Anesth Analg 103 (2006): 1466-8
- Baetz M, Malcolm D "Serotonin syndrome from fluvoxamine and buspirone." Can J Psychiatry 40 (1995): 428-9
- Tissot TA "Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use." Anesthesiology 98 (2003): 1511-1512
- Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763
- Ailawadhi S, Sung KW, Carlson LA, Baer MR "Serotonin syndrome caused by interaction between citalopram and fentanyl." J Clin Pharm Ther 32 (2007): 199-202
- Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5
- Mugele J, Nanagas KA, Tormoehlen LM "Serotonin Syndrome Associated With MDPV Use: A Case Report." Ann Emerg Med (2012):
- "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories, Philadelphia, PA.
- Turkel SB, Nadala JG, Wincor MZ "Possible serotonin syndrome in association with 5-HT3 antagonist agents." Psychosomatics 42 (2001): 258-60
- Shapiro RE, Tepper SJ "The serotonin syndrome, triptans, and the potential for drug-drug interactions." Headache 47 (2007): 266-9
- Achamallah NS "Visual hallucinations after combining fluoxetine and dextromethorphan ." Am J Psychiatry 149 (1992): 1406
- Goldberg RJ, Huk M "Serotonin syndrome from trazodone and buspirone." Psychosomatics 33 (1992): 235-6
- Lantz MS, Buchalter E, Giambanco V "St. John's wort and antidepressant drug interactions in the elderly." J Geriatr Psychiatr Neurol 12 (1999): 7-10
- Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7
- Wigen CL, Goetz MB "Serotonin syndrome and linezolid." Clin Infect Dis 34 (2002): 1651-2
- Metz A "Interaction between fluoxetine and buspirone." Can J Psychiatry 35 (1990): 722-3
- Tahir N "Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram." J Am Med Dir Assoc 5 (2004): 111-3
- Lane R, Baldwin D "Selective serotonin reuptake inhibitor--induced serotonin syndrome: review." J Clin Psychopharmacol 17 (1997): 208-21
- Insler SR, Kraenzler EJ, Licina MG, Savage RM, Starr NJ "Cardiac surgery in a patient taking monoamine oxidase inhibitors - an adverse fentanyl reaction." Anesth Analg 78 (1994): 593-7
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
- Harvey AT, Preskorn SH "Interactions of serotonin reuptake inhibitors with tricyclic antidepressants." Arch Gen Psychiatry 52 (1995): 783-4
- Laird LK "Issues in the monopharmacotherapy and polypharmacotherapy of obsessive-compulsive disorder." Psychopharmacol Bull 32 (1996): 569-78
- Insel TR, Roy BF, Cohen RM, Murphy DL "Possible development of the serotonin syndrome in man." Am J Psychiatry 139 (1982): 954-5
- Smith DL, Wenegrat BG "A case report of serotonin syndrome associated with combined nefazodone and fluoxetine." J Clin Psychiatry 61 (2000): 146
- Bernard L, Stern R, Lew D, Hoffmeyer P "Serotonin syndrome after concomitant treatment with linezolid and citalopram." Clin Infect Dis 36 (2003): 1197
- Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75
- Manos GH "Possible serotonin syndrome associated with buspirone added to fluoxetine." Ann Pharmacother 34 (2000): 871-4
- Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
- Giese SY, Neborsky R "Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl." Plast Reconstr Surg 107 (2001): 293-4
- Mason BJ, Blackburn KH "Possible serotonin syndrome associated with tramadol and sertraline coadministration." Ann Pharmacother 31 (1997): 175-7
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
- Gillman PK "Linezolid and serotonin toxicity." Clin Infect Dis 37 (2003): 1274-5
- Taylor JJ, Wilson JW, Estes LL "Linezolid and serotonergic drug interactions: a retrospective survey." Clin Infect Dis 43 (2006): 180-7
- Fischer P "Serotonin syndrome in the elderly after antidepressive monotherapy." J Clin Psychopharmacol 15 (1995): 440-2
- Margolese HC, Chouinard G "Serotonin syndrome from addition of low-dose trazodone to nefazodone." Am J Psychiatry 157 (2000): 1022
- Hunter B, Kleinert MM, Osatnik J, Soria E "Serotonergic syndrome and abnormal ocular movements: worsening of rigidity by remifentanil?" Anesth Analg 102 (2006): 1589
- "Product Information. Prozac (fluoxetine)." Dista Products Company, Indianapolis, IN.
- Lee J, Franz L, Goforth HW "Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine." Psychosomatics 50 (2009): 638-9
- Dannawi M "Possible serotonin syndrome after combination of buspirone and St John's Wort." J Psychopharmacol 16 (2002): 401
- Noble WH, Baker A "MAO inhibitors and coronary artery surgery: a patient death." Can J Anaesth 39 (1992): 1061-6
- "Product Information. Oleptro (traZODone)." Labopharm Inc, Laval, AL.
- Hansen TE, Dieter K, Keepers GA "Interaction of fluoxetine and pentazocine." Am J Psychiatry 147 (1990): 949-50
- Packer S, Berman SA "Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid." Am J Psychiatry 164 (2007): 346-7
- John L, Perreault MM, Tao T, Blew PG "Serotonin syndrome associated with nefazodone and paroxetine." Ann Emerg Med 29 (1997): 287-9
- "Product Information. Imitrex (sumatriptan)." Glaxo Wellcome, Research Triangle Park, NC.
- Mathew NT, Tietjen GE, Lucker C "Serotonin syndrome complicating migraine pharmacotherapy." Cephalalgia 16 (1996): 323-7
- Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin Psychopharmacol 12 (1997): 181-2
- Reeves RR, Bullen JA "Serotonin syndrome produced by paroxetine and low-dose trazodone." Psychosomatics 36 (1995): 159-60
- Gardner DM, Lynd LD "Sumatriptan contraindications and the serotonin syndrome." Ann Pharmacother 32 (1998): 33-8
Nome generico: fentanyl
Marchio commerciale: Duragesic, Abstral, Fentora, Subsys, Actiq, Ionsys, Lazanda, Onsolis, Sublimaze
Sinonimo: Fentanyl Patch, FentaNYL
Nome generico: imipramine
Marchio commerciale: Tofranil, Tofranil-PM
Sinonimo: Imipramine
In corso di controllo compatibilità e interazioni farmacologiche vengono utilizzati i dati presi dalle fonti: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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